Your Patient's Pharmacogenetic Results and Recommendations

How to Utilize This Page

These pharmacogenetic clinical implications and recommendations are based on the Clinical Pharmacogenetic Implementation Consortium (CPIC) Guidelines, FDA Table of Pharmacogenetic Associations, and FDA labeling. The pharmacogenetic results and accompanying clinical implications and therapeutic recommendations predict the function of drug metabolizing enzymes, drug transporters, and drug target proteins based on the genetic variants that encode these proteins.

Note: This information is based on genotype alone and does not consider possible phenoconversion. Phenoconversion occurs when a patient is taking a medication that induces or inhibits the drug metabolizing enzyme, which can change the predicted phenotype. Calculators such as the CYP2D6 Phenoconversion Calculator can be utilized to determine clinical phenotype in cases of phenoconversion.

Pharmacogenetic test results, their predicted clinical implications, and recommendations should be used as a tool and one piece of information along with other patient-specific factors (e.g., renal function, hepatic function, sex, environment, comorbid diseases) to make prescribing decisions.